FIGURE 6.
Human MAIT cells induce maturation of primary blood DCs. (A) Monocytes, CD1c DCs, and PDCs were gated as shown in Supplemental Fig. 4. Depicted is the cell surface expression of CD40 (upper panels) and CD80 (lower panels) in cells that were left unstimulated (green) or were stimulated for 16 h with 5-A-RU/MG, in the presence (pink) or absence (light blue) of anti-MR1 blocking Ab. (B–D) Cumulative data for seven donors (six for PDCs) depicting geometric mean fluorescence intensity (MFI) for CD80 (black), CD86 (blue), and CD40 (purple) for cells that were left unstimulated or stimulated with 5-A-RU/MG, in the presence or absence of anti-MR1 blocking Ab. Data are depicted as box-and-whisker plots, with all points indicated, ±SD. *p < 0.05.