| In the area of precision medicine, students will participate in: |
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Ongoing patient care activities to support clinical implementation of pharmacogenomic initiatives, including:
CYP2C19-guided clopidogrel therapy in the cardiac catheterization laboratory TPMT-guided dosing of azathioprine, mercaptopurine, and thioguanine primarily for pediatric hematology/oncology patients and pediatric and adult gastroeneterology patients CYP2D6-guided dosing of select opioids within primary care or pain clinics CYP2D6/CYP2C19-guided dosing of select antidepressants in adult psychiatry clinics HLA testing in select primary care, neurology, or HIV clinics IL28B (IFNL3) guided-dosing of pegylated interferon as needed in hepatitis C clinic
Support of and participation in the Personalized Medicine Subcommittee and related Pharmacy & Therapeutics committee activities for clinical implementation of genotype-guided therapies. Case-based discussions on pharmacogenetics and precision medicine, including clinical utility of selected drug-gene pairs, and steps for clinical implementation of pharmacogenetics in a health care setting. Ongoing medical evidence review and evaluation for existing and potential drug-gene pair implementations. If available, participate in pharmacogenomic laboratory activities such as sample collection, DNA isolation, polymerase chain reaction, etc. Development of educational materials for health care professionals and patients on pharmacogenomics and precision medicine.
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| In the area of evidence-based medicine, students will participate in: |
Ongoing daily and systematic review of medical literature, FDA alerts, and new drug approvals. Weekly discussions of recently published pharmacogenetic literature. Research, writing, and publication of four articles (one per week) for publication in the pharmacogenomics newsletter. Discussions on clinical trial design and analysis, professional writing, editing, publishing, and strategies for keeping up with the medical literature.
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| Rotation assignments/activities will include: |
Patient care responsibilities in targeted areas (as listed above), including weekly patient case discussions Weekly discussion of current pharmacogenomics literature Journal club presentation Patient case or topic presentation Research and writing of newsletter articles for provider education Design of a mock clinical decision support algorithm for a sample gene-drug pair Research and writing of a clinically actionable gene-drug pair monograph Design of a mock pharmacogenes chip (including selection of variants based on clinical evidence) Attendance and participation in department journal clubs, seminars, and other pertinent educational activities.
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