Table 3. Cox Proportional Hazards Regression Models of Autonomic Dysfunction and Individual Autonomic Symptoms for Disease Progression and Survival.
| Outcome Variable | HR (95% CI) | P Value |
|---|---|---|
| Time to Autonomic Dysfunctiona | ||
| First milestone | 0.86 (0.83-0.89) | <.001 |
| Regular falls | 0.88 (0.84-0.92) | <.001 |
| Wheelchair | 0.93 (0.89-0.97) | .002 |
| Speech | 0.93 (0.84-1.03) | .18 |
| Severe dysphagia | 0.97 (0.88-1.07) | .57 |
| Cognitive impairment | 0.90 (0.85-0.95) | <.001 |
| Care placement | 0.91 (0.87-0.96) | .001 |
| Survival | 0.92 (0.88-0.96) | <.001 |
| Time to Autonomic Symptomsa | ||
| Orthostatic hypotension | ||
| First milestone | 0.94 (0.91-0.97) | <.001 |
| Survival | 0.92 (0.89-0.95) | <.001 |
| Upper gastrointestinal tract symptoms | ||
| First milestone | 0.93 (0.90-0.96) | <.001 |
| Survival | 0.93 (0.91-0.96) | <.001 |
| Constipation | ||
| First milestone | 0.94 (0.90-0.97) | .001 |
| Survival | 0.95 (0.90-0.98) | .005 |
| Urinary symptoms | ||
| First milestone | 0.92 (0.89-0.95) | <.001 |
| Survival | 0.94 (0.91-0.97) | <.001 |
| Erectile dysfunction | ||
| First milestone | 0.92 (0.89-0.96) | <.001 |
| Survival | 0.86 (0.82-0.89) | <.001 |
| Sweating abnormalities | ||
| First milestone | 0.88 (0.84-0.92) | <.001 |
| Survival | 0.89 (0.86-0.93) | <.001 |
Abbreviation: HR, hazard ratio.
a
The different forms of the main explanatory variables were considered in turn in different Cox proportional hazards regression models (not in the same model).