Table 2.
Patients with high cognitive predictive scores have a substantially increased hazard ratio for global cognitive impairment compared to those with scores in the lowest quartile.
| Quartile
|
||||
|---|---|---|---|---|
| 1 | 2 | 3 | 4 | |
|
| ||||
| 0 to <0.0954 | 0.0954 to <0.1958 | 0.1958 to <0.3789 | 0.3789 to ≤1 | |
| Discovery population | ||||
| Parkinson’s disease (N) | 338 | 337 | 337 | 338 |
| Cognitive predictive scores (range) | 0.0076–0.0954 | 0.0954–0.1955 | 0.1961–0.3788 | 0.3789–1.0000 |
| HR (95% CI)# | 1 | 2.7 (1.2–5.9) | 6.0 (2.9–12.5) | 21.6 (10.9–42.9) |
| p value | 0.013 | <0.0001 | <0.0001 | |
| Validation population | ||||
| Parkinson’s disease (N) | 375 | 320 | 281 | 156 |
| Cognitive predictive scores (range) | 0.0089–0.0951 | 0.0955–0.1951 | 0.1959–0.3776 | 0.3809–0.9729 |
| HR (95% CI)# | 1 | 3.2 (1.6–6.7) | 8.3 (4.2–16.2) | 18.4 (9.4–36.1) |
| p value | 0.0015 | <0.0001 | <0.0001 | |
#
Hazard ratio (HR) and confidence intervals (CI) were calculated using Cox regression models.