Table 1.
Patient Screening/Baseline Characteristics
| Cohort 1 1.4 × 1011 DRP n=3 | Cohort 2 6 × 1011 DRP n=3 | Cohort 3 3 × 1012 DRP n=3 | Total n=9 | |
|---|---|---|---|---|
| Demographics | ||||
|
| ||||
| Age, y, mean (SD) | 53 (7.0) | 55 (4.6) | 47.7 (9.0) | 51.9 (7.0) |
| Male, n | 3 | 2 | 2 | 7 |
| Race, n | ||||
| Caucasian | 3 | 3 | 1 | 7 |
| African American | 0 | 0 | 2 | 2 |
|
| ||||
| NYHA status, number (%) | ||||
|
| ||||
| NYHA Class | 3 (100) | 3 (100) | 3 (100) | 3 (100) |
|
| ||||
| Cardiac, mean (SD) | ||||
|
| ||||
| MLWHFQ (points) | 46.0 (31.8) | 46.3 (20.5) | 40.7 (20.2) | 44.3 (21.6) |
| 6-min walk (meters) | 376.7 (29.3) | 421.7 (129.3) | 386.3 (115.2) | 394.9 (90.2) |
| VO2 max (mL·kg·min) | 14.6 (2.5) | 13.0 (2.8) | 14.9 (2.9) | 14.2 (2.5) |
| LVESV (mL) | 213.3 (44.9) | 252.0 (86.6) | 210.7 (47.4) | 225.3 (57.8) |
| LVEF (%) | 24.3 (6.0) | 20.3 (4.5) | 22 (3.6) | 22.2 (4.5) |
| NT-Pro BNP (pg/mL) | 1857 (1369) | 3084 (1954) | 10644 (17373) | 5195 (9688) |
|
| ||||
| Medical history, number | ||||
|
| ||||
| Coronary artery disease | 2 | 1 | 1 | 4 |
| Diabetes mellitus | 1 | 0 | 2 | 3 |
| Hypertension | 1 | 0 | 2 | 3 |
| Previous MI | 2 | 1 | 1 | 4 |
|
| ||||
| Physical findings, mean (SD) | ||||
|
| ||||
| Systolic blood pressure (mm Hg) | 105.3 (20) | 98.0 (5.3) | 105.3 (4.2) | 102.9 (11.2) |
| Diastolic blood pressure (mm Hg) | 69.3 (1.2) | 68.3 (10.4) | 79.0 (1.7) | 72.2 (7.4) |
| Body weight (kg) | 94.0 (17.7) | 85.0 (13.6) | 94.7 (21.1) | 91.2 (16.0) |
DRP, DNase resistant particles; NYHA, New York Heart Association; MLWHFQ, Minnesota Living with Heart Failure Questionnaire; VO2 max, maximal oxygen uptake; LVESV, left ventricular end-systolic volume; LVEF, left ventricular ejection fraction; MI, myocardial infarction.