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. 2018 Mar 21;8:4984. doi: 10.1038/s41598-018-22676-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Individual gait profiles of patients with MS. (A) Kinematic gait parameters for single subjects with MS (n = 37) walking at half-maximal gait speed (v_max50%) represented in a color-coded grading system. Twenty-eight parameters were classified as normal/unchanged (grey), pathologically reduced (blue) or pathologically increased (red) based on normative data obtained from 20 healthy controls. (B) Graphs show changes in selected gait parameters in subjects with MS in relation to walking speed. Values located outside the interval of the mean ± 2 SD of 20 healthy control subjects (dashed grey line) were defined as pathological. Data for the weakest leg is displayed in red, while values for the strongest leg are shown in blue. Abbreviations: AP: anteroposterior; ASI: asymmetry index; COM: centre of mass; COV: coefficient of variation; disp.: dispersion; deg: degrees; DLS: double-limb support; il. coord.: inter-limb coordination; s: strongest leg; MdS: midswing; ML: mediolateral; Pat. ID: patient identification number; ROM: range of motion; SD: standard deviation; traj.: trajectory; w- weakest leg.