Table 4.
Cognitive measures associated with unadjusted or residual HC SUVR
| Sample | Data type | Predictor | Estimate | SE | t value | p value | Adj. p value (4 tests) |
|---|---|---|---|---|---|---|---|
|
|
|||||||
| Memory factor score as outcome variable | |||||||
|
| |||||||
| All(N = 147) | pvc | HC SUVR | −0.677 | 0.359 | −1.887 | 0.061 | 0.245 |
| HC SUVR residuals | −1.237 | 0.451 | −2.741 | 0.007 | 0.028 | ||
| non-pvc | HC SUVR | −0.496 | 0.517 | −0.960 | 0.339 | >1.000 | |
| HC SUVR residuals | −1.696 | 0.759 | −2.234 | 0.027 | 0.108 | ||
| Aβ+ (n = 46) | pvc | HC SUVR | −1.324 | 0.600 | −2.208 | 0.033 | 0.133 |
| HC SUVR residuals | −2.054 | 0.710 | −2.894 | 0.006 | 0.025 | ||
| non-pvc | HC SUVR | −1.450 | 0.874 | −1.659 | 0.105 | 0.421 | |
| HC SUVR residuals | −3.218 | 1.121 | −2.870 | 0.007 | 0.027 | ||
| Aβ− (n = 101) | pvc | HC SUVR | 0.018 | 0.440 | 0.042 | 0.967 | >1.000 |
| HC SUVR residuals | −0.051 | 0.636 | −0.080 | 0.937 | >1.000 | ||
| non-pvc | HC SUVR | 0.365 | 0.610 | 0.599 | 0.551 | >1.000 | |
| HC SUVR residuals | 0.917 | 1.049 | 0.874 | 0.384 | >1.000 | ||
|
Executive factor score as outcome variable
|
|||||||
| All(N = 147) | pvc | HC SUVR | −0.019 | 0.269 | −0.069 | 0.945 | >1.000 |
| HC SUVR residuals | −0.219 | 0.342 | −0.641 | 0.522 | >1.001 | ||
| non-pvc | HC SUVR | −0.011 | 0.383 | −0.029 | 0.977 | >1.002 | |
| HC SUVR residuals | −0.603 | 0.569 | −1.060 | 0.291 | >1.003 | ||
| Aβ+ (n = 46) | pvc | HC SUVR | −0.176 | 0.483 | −0.365 | 0.717 | >1.000 |
| HC SUVR residuals | −0.327 | 0.593 | −0.552 | 0.584 | >1.000 | ||
| non-pvc | HC SUVR | −0.326 | 0.685 | −0.475 | 0.637 | >1.000 | |
| HC SUVR residuals | −0.937 | 0.927 | −1.011 | 0.319 | >1.000 | ||
| Aβ− (n = 101) | pvc | HC SUVR | 0.018 | 0.358 | 0.051 | 0.959 | >1.000 |
| HC SUVR residuals | −0.385 | 0.516 | −0.747 | 0.457 | >1.000 | ||
| non-pvc | HC SUVR | 0.133 | 0.497 | 0.268 | 0.789 | >1.000 | |
| HC SUVR residuals | −0.622 | 0.854 | −0.729 | 0.468 | >1.000 | ||
Aβ+/−, elevated/low amyloid-β groups; Adj. p, p values adjusted for multiple comparison using the Bonferroni method; HC, hippocampus; pvc, partial volume correction using geometric transfer matrix method; SE, standard error; SUVR, standardized uptake value ratio. NOTE: Cerebellar cortex was used as reference for all SUVR shown. Separate multiple linear regression models were run. All models covarying for race, age, sex, and education. Bold values indicate significant association between FTP measurements in the CP and nearby ROI (p < 0.05).