Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Dec 20;7:e40618. doi: 10.7554/eLife.40618

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018, Forcier et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

PMC Copyright notice

Appendix 2—figure 1. — (A) Measurements of $t_{+}^{raw}$ (in 250 µM cAMP) vs $t_{-}^{raw}$ (in 0 µM cAMP) for promoters in which the CRP binding site has been replaced by a non-functional ‘null’ site. As expected, these data lie close to the $t_{+}^{raw} = t_{-}^{raw}$ diagonal (dotted line). (B) Upon closer inspection, however, we found that $t_{+}^{raw}$ values consistently fell slightly below corresponding $t_{-}^{raw}$ values. Using least-squares fitting we found that, on average, $t_{+}^{r a w} / t_{-}^{r a w} = {0.852}_{- 0.053}^{+ 0.056}$ where uncertainties indicate a 95% confidence interval (reflecting 1.96 times the standard error of the mean in log space). To correct for this bias, we plot and fit models to $t_{+} = t_{+}^{raw}$ and $t_{-} = 0.855 \times t_{-}^{raw}$ throughout this paper.