Table 4.
Demographics and clinical characteristics of the ASD study subjects, when ASD subjects subdivided into the high, normal, and low IL-1ß/IL-10 ratios groups.
| ASD subjects subgrouped based on IL-1ß/IL-10 ratios | |||
|---|---|---|---|
| High ratio (N = 51) | Normal ratio (N = 47) | Low ratio (N = 14) | |
| AGE | |||
| Median (range) | 11.8 year (2.5–30.0) | 13.4 year (3.8–30.0) | 11.1 year (5.8–19.8) |
| Mean ± SD | 12.3 ± 6.3 year | 13.1 ± 5.9 year | 11.8 ± 4.9 year |
| Gender (M:F and %) | 43:8 (84.3%: 15.7%) | 41:6 (87.2%: 12.8%) | 13:1 (92.9%: 7.1%) |
| Ethnicity | AAa 5, Asian 10, C 36 | AA 2, Asian 9, Mixed 2, C 34 | AA 1, Asian 2, C 11 |
| Cognitive activity (< 1st %) | 37/51 (72.5%) | 32/47 (70.2%) | 11/14 (78.6%) |
| Disturbed sleep | 16/51 (31.4%) | 11/47 (23.4%) | 8/14 (57.1%)c |
| GI symptomsd | 33/51 (64.7%) | 32/47 (68.1%) | 11/14 (78.6%) |
| History of NFA | 29/51 (56.9%) | 21/47 (44.7%) | 11/14 (78.6%)b |
| Seizure disorders | 5/51 (9.8%) | 6/47 (12.8%) | 3/14 (21.4%) |
| SAD | 7/51 (14.9%) | 9/47 (19.1%) | 3/14 (21.4%) |
| Allergic rhinitis | 11/51 (21.6%) | 10/47 (21.3%) | 2/14 (14.3%) |
| Asthma | 8/51 (11.9%) | 4/47 (8.5%) | 0 |
AA, African American; ASD, autism spectrum disorder; C, Caucasian; GI, gastrointestinal; NFA, non-IgE mediated food allergy; SAD, specific antibody deficiency; SD, standard deviation.
Significantly different in frequencies by Chi-Square test and Likelihood Ratio (p < 0.05). Frequency of history of NFA is higher in the low ratio ASD subgroup than in the normal ratio ASD subgroup (p < 0.05 by Fisher's exact test)
Frequency of disturbed sleep was higher in the low ratio ASD subgroup than in the normal ratio ASD subgroup (p < 0.05 by Fisher's exact test).
GI symptoms present at the time of sample obtainment: Constipation is the most common complaint.