Table 9.
Assessment of correlations between PBMo cytokine production and markers of ETC efficiency (ALR/PLR, MRC/PLR, and RC/PLR).
| Cytokine showed correlation with ALR/PLR, MRC/PLR, and RC/PLRa | IL-1ß/IL-10 ratiod based ASD subgroups | Non-ASD controls (N = 38) | ||
|---|---|---|---|---|
| High ratio (N = 56) | Normal ratio (N = 59) | Low ratio (N = 22) | ||
| ALR/PLRc | ||||
| Ratio (LPS) | -0.1907b | −0.359 (p < 0.01) | 0.4033 | –0.0631 |
| Ratio (zymosan) | −0.3285 (p < 0.02) | −0.0309 | 0.0932 | 0.2167 |
| IL-1ß (LPS) | −0.0384 | 0.3122 (p < 0.02) | 0.3303 | −0.1191 |
| IL-1ß (zymosan) | 0.0289 | 0.0965 | 0.4783 (p < 0.05) | 0.0379 |
| IL-10 (LPS) | 0.3468 (p < 0.01) | 0.0506 | 0.2298 | 0.1267 |
| MRC/PLR | ||||
| Ratio (LPS) | −0.1415 | 0.473 (p < 0.0005) | 0.2569 | −0.1251 |
| Ratio (CL097) | −0.0679 | −0.0954 | −0.5089 (p < 0.02) | −0.0501 |
| IL-1ß (LPS) | 0.0019 | 0.392 (p < 0.005) | 0.2976 | −0.1587 |
| IL-1ß (zymosan) | 0.0267 | 0.1176 | 0.5088 (p < 0.02) | 0.0333 |
| IL-10 (LPS) | 0.356 (p < 0.01) | −0.024 | 0.2863 | 0.0123 |
| RC/PLR | ||||
| Ratio (LPS) | –0.1201 | 0.5029 (p < 0.0005) | 0.1836 | −0.1067 |
| Ratio (CL097) | −0.0677 | 0.1154 | −0.5345 (p < 0.01) | −0.0992 |
| IL-1ß (LPS) | 0.025 | 0.4204 (p < 0.005) | 0.2677 | −0.1417 |
| IL-1ß (zymosan) | 0.0355 | 0.1225 | 0.4607 (p < 0.05) | −0.0355 |
| IL-10 (LPS) | 0.3504 (p < 0.01) | 0.0377 | 0.3321 | −0.0278 |
a
The relationship between levels of cytokine produced by PBMo and ALR/PLR, MRC/PLR, or RC/PLR. Results are shown in cytokines that showed positive or negative associations with ETC efficiency parameters in at least one of ASD subgroups or non-ASD controls. Stimulants used for PBMo cultures are shown in the parentheses. The details of PBMo culture conditions are shown in the method section.
b
Correlation coefficient by Spearman Test. When the results are significant, the values are shown with p-values.
c
Abbreviations used: please see Table 3.
d
Definition of high, normal, and low ratio groups are detailed in the method section.