Table 4.
Findings in Subcortical Regions
| Imaged pathology | Tracer(s) used | Article | Substantia nigra | Subcortical hypothalamus | Thalamus | Subthalamic nucleus | Pons | Striatum | Globus pallidus | Caudate | Putamen | Cerebral white matter |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tau/amyloid Iimaging | Barrio and colleagues43 RHT (n = 14) > CN (n = 28) | – | x | x | – | x | x | – | – | – | – | |
| [F-18] FDDNP | Barrio and colleagues43 RHT (n = 14) > AD (n = 24) | – | x | NS | – | x | x | – | – | – | – | |
| [F-18] FDDNP | Small and colleagues48* RHT (5) >CN (5) | – | – | x | x | – | – | – | x | x | x | |
| Tau only imaging | [18F] T807, AV1451 | Jordan and colleagues46 (n = 1) | – | – | – | – | – | – | x | – | – | – |
| 18F-Florbetapir, T807 | Mitsis and colleagues47 (n = 1) | x | – | – | – | – | – | x | – | x | – | |
| Neuroinflammation imaging | 18 kda TSPO | Coughlin and colleagues44 (n = 12) > CN (n = 11) | – | – | – | – | – | – | – | – | – | – |
| [11C] DPA-713 TSPO | Coughlin and colleagues45 (n = 11) > CN (n = 9) | – | – | – | – | – | – | – | – | – | – | |
| Proportion of patients with significant changes vs. CN; Small and colleagues48 excluded (Patient n) | 1 (1) | 1 (14) | 1 (14) | 1 (5) | 1 (14) | 1 (14) | 1 (2) | 1 (5) | 1 (6) | 1 (5) | ||