Table 3. Neuropathologic Findings by Parkinson Disease Subtypesa.
| Neuropathologic Stage | No. (%) | P Valueb | |||
|---|---|---|---|---|---|
| Total | Mild-Motor Predominant | Intermediate | Diffuse Malignant | ||
| Braak | |||||
| Stage 4 | 2 (1.8) | 0 | 1 (2.6) | 1 (5.6) | .37 |
| Stage 5 | 9 (8.1) | 4 (7.4) | 5 (12.8) | 0 | |
| Stage 6 | 100 (90.1) | 50 (92.6) | 33 (84.6) | 17 (94.4) | |
| Lewy pathology | |||||
| Brainstem | 1 (0.9) | 0 | 1 (2.6) | 0 | .44 |
| Limbic | 16 (14.4) | 6 (11.1) | 6 (15.4) | 4 (22.2) | |
| Neocortical | 94 (84.7) | 48 (88.9) | 32 (82.1) | 14 (77.8) | |
| Aβ deposition (Thal) | |||||
| Phase 0 | 25 (22.5) | 12 (22.2) | 8 (20.5) | 5 (27.8) | .35 |
| Phase 1 | 21 (18.9) | 9 (16.7) | 7 (18.0) | 5 (27.8) | |
| Phase 2 | 9 (8.1) | 8 (14.8) | 0 (0.0) | 1 (5.6) | |
| Phase 3 | 35 (31.5) | 17 (31.5) | 14 (35.9) | 4 (22.2) | |
| Phase 4 | 13 (11.7) | 7 (13.0) | 5 (12.8) | 1 (5.6) | |
| Phase 5 | 8 (7.2) | 1 (1.9) | 5 (12.8) | 2 (11.1) | |
| Neurofibrillary tangle (Braak and Braak) | |||||
| Stage 0 | 6 (5.4) | 1 (1.9) | 5 (12.8) | 0 | .66 |
| Stage I | 27 (24.3) | 15 (27.8) | 8 (20.5) | 4 (22.2) | |
| Stage II | 50 (45.1) | 25 (46.3) | 16 (41.0) | 9 (50.0) | |
| Stage III | 19 (17.1) | 9 (16.7) | 7 (18.0) | 3 (16.7) | |
| Stage IV | 6 (5.4) | 4 (7.4) | 2 (5.1) | 0 | |
| Stage V | 2 (1.8) | 0 | 0 | 2 (11.1) | |
| Stage VI | 1 (0.9) | 0 | 1 (2.6) | 0 | |
| Neuritic plaque (CERAD) | |||||
| Absent | 44 (39.6) | 22 (40.7) | 12 (30.8) | 10 (55.6) | .27 |
| Sparse | 39 (35.1) | 20 (37.0) | 15 (38.5) | 4 (22.2) | |
| Moderate | 25 (22.5) | 12 (22.2) | 10 (25.6) | 3 (16.7) | |
| Frequent | 3 (2.7) | 0 | 2 (5.1) | 1 (5.6) | |
| Alzheimer disease pathology (NIA) | |||||
| Not | 28 (25.2) | 13 (24.1) | 9 (23.1) | 6 (33.3) | .60 |
| Low | 63 (56.8) | 31 (57.4) | 22 (56.4) | 10 (55.6) | |
| Intermediate | 18 (16.2) | 10 (18.5) | 7 (18.0) | 1 (5.6) | |
| High | 2 (1.8) | 0 | 1 (2.6) | 1 (5.6) | |
Abbreviations: Aβ, amyloid β; CERAD, Consortium to Establish a Registry for Alzheimer’s Disease score; NIA, National Institute on Aging score.
a
P value from comparisons using Kruskal-Wallis test. Pairwise comparisons were adjusted by number of comparisons.
b
Significant adjusted pairwise comparisons.