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. 2014 Mar 7;2014(3):CD009850. doi: 10.1002/14651858.CD009850.pub2
Study Reason for exclusion
Abboud 2012 Retrospective chart review of all patients admitted to intensive care with a diagnosis of viral bronchiolitis from 2006 to 2010. 113 patients met inclusion criteria of < 12 months, initiation of HFNC on admission
Arora 2012 Prospective observational study to measure nasopharyngeal effects of HFNC in infants with bronchiolitis. 25 infants enrolled
Hedge 2013 Case series of three patients with air leak syndrome who were also treated with HFNC
Hilliard 2012 Prospective randomized controlled trial comparing HFNC versus head box oxygen therapy. 19 participants enrolled, all with viral bronchiolitis
Hough 2011 Prospective physiological study comparing HFNC at different flow rates. 13 participants enrolled, all with bronchiolitis
McGinley 2009 Prospective observational study of 12 participants with obstructive apnoea‐hypopnoea syndrome treated with nasal insufflation at 20 L/min
McKiernan 2010 Retrospective chart review comparing intubation rates of infants with bronchiolitis admitted before and in the season after HFNC was implemented. 115 participants included in the review
Milesi 2013 Prospective physiological study of 21 infants < six months with viral bronchiolitis and HFNC therapy. Pharygneal and oesophageal pressures measured at different flow rates
Schibler 2011 Retrospective chart review of infants < 24 months admitted to PICU between January 2005 and December 2009, requiring HFNC therapy. 298 infants included in the review
Spentzas 2009 Observational study of all participants (newborn to 12 years) requiring HFNC, admitted between January 2005 and January 2007 to PICU. 46 participants included in the study
Wing 2012 Retrospective chart review of all patients admitted from ED to PICU with acute respiratory insufficiency from January 2006 to December 2009. Patients admitted before HFNC availability were compared with patients admitted after HFNC became available (two cohorts, before and after implementation of clinical guidelines). 848 participants included in the review