Fig. 5.
Paw withdrawal latencies before and after intraplantar (A) or intrathecal (B) injection of 0.1 μg of PGE2 in wild-type and mutant mice. Mutant mice showed significantly less thermal allodynia compared with wild-type mice after both intraplantar (p < 0.01, repeated measures ANOVA) or intrathecal (p < 0.05) administration of PGE2. Data are presented as the mean latency in seconds ± SEM; n = 5 per group.Asterisks indicate significant differences between the groups (*p < 0.05; **p < 0.01, Fisher’s PLSD test).