Fig. 6.
Effect of nerve injury on withdrawal responses to thermal and mechanical stimulation in wild-type and mutant mice.A, Paw withdrawal latencies to thermal stimulation. Data are presented as the mean time in seconds ± SEM to paw withdrawal of the injured (ipsilateral) and the noninjured (contralateral) sides;n = 3 per group. Both groups developed thermal allodynia of comparable magnitude on the injured side.B, Paw withdrawal thresholds to mechanical stimulation. Data are presented as the mean von Frey hair threshold in grams ± SEM of the injured (ipsilateral) and the noninjured (contralateral) sides. There was no difference between the groups in the response to acute thermal or mechanical stimulation (day 0), and the threshold did not change in the nerve-injured animals.