Table 1.
Summary of the potentiating effect of NT-3 at developing motoneurons
| SSC amplitude (pA) | ||
|---|---|---|
| Control | NT-3 treatment | |
| Manipulated synapse | ||
| Naive nerve terminal | 50.9 ± 6.4 (9) | 75.3 ± 5.8 (8)* |
| Vacated nerve terminal | 75.8 ± 7.4 (10) | ND |
| Natural synapse | 155.3 ± 19.1 (27) | 184.2 ± 33.1 (22) |
| Natural synapse treated with d-Tc | 48.9 ± 3.4 (12) | 110.4 ± 13.2 (9)* |
Drugs were bath-applied to day 1 cultures and removed by several washes with Ringer’s solution on day 3 for the recordings of spontaneous synaptic currents (SSCs). SSCs were recorded from either manipulated synapses or natural synapses by whole-cell voltage-clamped myocyte (VH = −70 mV).
The values were shown as mean ± SE (n). n, Number of synapses.
ND, Not determined.
*
p < 0.05 as compared with control.