Table 3.
IC50 values and Hill slopes of complex I inhibitors competing for [3H]DHR binding
| Inhibitor | Striatum | Dentate gyrus | Cerebellum |
|---|---|---|---|
| Rotenone | |||
| IC50(nm) | 19.9 ± 5.0 | 11.2 ± 2.0 | 8.2 ± 1.3 |
| nH | 1.07 ± 0.04 | 1.06 ± 0.03 | 1.10 ± 0.08 |
| Meperidine | |||
| IC50 (μm) | 34.4 ± 1.3 | 56.7 ± 2.2 | 50.9 ± 6.9 |
| nH | 1.03 ± 0.05 | 1.12 ± 0.11 | 1.14 ± 0.09 |
| Amobarbitol | |||
| IC50 (μm) | 427 ± 36 | 374 ± 25 | 426 ± 33 |
| nH | 3.08 ± 0.36* | 2.83 ± 0.23** | 2.04 ± 0.11** |
| MPP+ | |||
| IC50 (mm) | 3.96 ± 0.49 | 4.73 ± 0.56 | 4.56 ± 0.24 |
| nH | 1.65 ± 0.31* | 1.66 ± 0.12* | 1.82 ± 0.12** |
Values represent mean ± SEM; n = 4. [3H]DHR concentration was 5 nm, NADH concentration was 200 μm. *p < 0.05, **p < 0.005, compared with 1 by one-samplet test.