Figure 7.
Decreased levels of VMAT2 but not AADC in cNurr1AAVCre mice. Confocal analysis of SNc in wtAAVCre and cNurr1AAVCre mice at 4 months, as indicated. A–F, Confocal images show staining of AADC (red; A, D), TH (green; B, E), and double staining of both markers (C, F). Micrographs show that AADC expression appears expressed at normal levels in most cells with decreased levels of TH. G–L, Confocal images show staining for VMAT2 (red; G, J), Hu (H, K), and double staining of both markers (I, L). Micrographs show that VMAT2 is severely decreased in cNurr1AAVCre mice, whereas Hu is maintained at normal levels in essentially all cells with decreased VMAT2. Scale bar, 200 μm.