Figure 3.
KW6002 effect on cocaine-induced psychomotor activity in forebrain A2AR KO and striatum A2AR KO mice. A–D, The fb-A2AR KO and st-A2AR KO mice and their corresponding WT littermates were treated with KW6002 (3.3 mg/kg, i.p.) or vehicle 10 min before cocaine (25 mg/kg, i.p.) administration. Ambulation was recorded for 120 min after cocaine injection. KW6002 increases cocaine-induced ambulation in st-WT mice (n = 12; A) and fb-WT mice (n = 8; C). KW6002 attenuates cocaine-induced ambulation in st-A2AR KO mice (n = 8; C) and shows no additional effect on cocaine-induced ambulation in fb-A2AR KO mice (n = 8; D). #p < 0.05, comparing cocaine plus KW6002 to cocaine plus vehicle.