Figure 7.
Effects of the NMDA receptor antagonist APV on cholinergic signals evoked by nAChR agonists. a, b, Choline signals induced by nicotine (a) or ABT-089 (b) after infusions of saline (nicotine, red; ABT-089, green) or a low dose of APV (40 pmol). ABT-089, but not nicotine-evoked cholinergic activity was attenuated by this dose of APV. c, Reduction in nicotine- and ABT-089-evoked signal amplitudes (SEM) by APV infusions (nicotine, red bars; ABT-089; green bars; ***p < 0.001 saline vs APV.