Figure 3.
Cerebral vasculature analysis. A, Ventral view of large cerebral blood vessels of control (HIF-1αF/F) and neuronal HIF-1α-deficient (R1- and L7-HIF-1αΔ/Δ) mice that were perfused with India ink. B, Representative microscopic views of boxed area in diagram are shown. Brain sections from HIF-1αF/F and R1- and L7-HIF-1αΔ/Δ mice were immunostained for the endothelial cell-specific marker CD31 (green) for quantification of capillary numbers per area. *p < 0.05 compared with HIF-1αF/F; n = 4.