Figure 2.
AMG0347 produces hyperthermia in wild-type rats and mice but not in TRPV1-deficient mice. A, Effects of intravenous AMG0347 (doses indicated) or its vehicle on the colonic (deep body) temperature of rats at a neutral Ta of 28°C and on the abdominal (deep body) temperature of mice at a neutral Ta of 31°C. B, Effects of AMG0347, abdominal needle prick, or RTX on the abdominal temperature of TRPV1+/+ (wild-type) and TRPV1−/− (TRPV1-deficient) mice. When the stimulus was expected to result in hyperthermia (AMG0347 administration and needle prick), the experiment was conducted at a neutral Ta (31°C); when the stimulus was expected to result in hypothermia (RTX), the experiment was performed at a subneutral Ta (26°C). The number of animals in each group (n) is indicated.