Figure 5.
TLR2 signaling affects microglial, but not astroglial reactivity in denervated zones. A–D, CD11b (A, B) and GFAP (C, D) staining in lesion-reactive hippocampi of WT and TLR2-deficient mice at 5 d after lesion (n = 4). The arrows delineate reactive zones. The insets show high magnification images of microglia and astrocytes from the denervated outer molecular layer of the dentate gyrus. A, Inset, shows a cell doublet, consistent with proliferation, and an isolated CD11b+ cell. The morphology of cells identified by nuclear staining in the inset in B is less clearly defined because of weak CD11b staining. The GFAP staining shows the well defined laminar organization of glial response characteristic of the entorhinal lesion. Original magnification, 10 and 40×.