Figure 2.
Reduction of tau oligomers in mice immunized with TOMA. A–F, Confocal images of brain section from mice immunized control antibody (IgG group) or TOMA, stained with T22 (A, B) and 4G8 (C, D). Merge is shown in E and F. Mice receiving the control antibody (IgG group) showed abundant tau oligomers (showed in red; A) and a characteristic 4G8 immunoreaction pattern (showed in green; C). A remarkable reduction of tau oligomer (showed in red; B) was observed in mice immunized with TOMA. No difference was found using 4G8 (D). Scale bar, 25 μm. G, The graph represents the pixel quantitation exhibit by T22 and 4G8.