Table 2.
Single-channel parameters of AITC-induced activation (in the absence of external Ca2+), Ca2+-induced potentiation, and Ca2+-induced inactivation obtained from outside-out patches at a holding potential of −80 mV
Phase |
Popen |
Burst duration (ms) |
Open time (ms) |
Close time (ms) |
Amplitude (pA) |
---|---|---|---|---|---|
Ca2+-free activation | 0.17 ± 0.11 | 11.7 ± 24.4 | 4.4 ± 5.9 | 78.5 ± 177 | 5.7 ± 0.4 |
Ca2+-induced potentiation | 0.51 ± 0.30 | 94.2 ± 133 | 6.1 ± 8.9 | 7.4 ± 25.6 | 3.1 ± 0.4 |
Ca2+-induced inactivation |
0.02 ± 0.01 |
4.1 ± 1.3 |
ND |
ND |
3.1 ± 0.4 |
Data show mean ± SD estimated from 1117 events pooled from four separate experiments. ND, Not determined.