Table 3.
Differences in the proximity between N and C termini in wild-type PS1 and FAD mutant PS1
|
Condition |
FITC lifetime (t2; mean ± SD; ps) |
|---|---|
| PS1 wild type (n = 55) | 1768 ± 141 |
| PS1 Δex9 (n = 36) | 1019 ± 221* |
| PS1 M139V (n = 9) | 1144 ± 54* |
| PS1 M146L (n = 36) | 1191 ± 342* |
| PS1 L166P (n = 23) | 830 ± 191* |
| PS1 L286V (n = 63) | 1054 ± 285* |
| PS1 G384A (n = 30) | 849 ± 124* |
| PS1 C410Y (n = 37) | 1162 ± 404* |
| PS1 E318G (n = 25) |
1817 ± 202 |
For the analysis of the effect of FAD PS1 mutations, CHO cells were transiently transfected with either wild-type PS1 or FAD mutant PS1. n, Cell number. *p < 0.01 compared with wild-type PS1 (ANOVA).