Figure 4.
Stereological quantitation of CAA and fibrillar plaque load. A-C, In 15-month-old APPsw mice, expression of human apoE4 (hApoE) and murine apoE (mApoE) resulted in significantly greater CAA load in leptomeningeal vessels (A), penetrating cortical vessels (B), and total cortical vessels (C) and parenchymal plaque load compared with mice expressing human apoE3. B-D, Expression of murine apoE also resulted in significantly higher levels of penetrating (B), total CAA (C), and parenchymal plaque load (D) compared with expression of human apoE4. D, Expression of both human apoE3 and apoE4 resulted in a dramatic reduction in parenchymal amyloid plaque load compared with mice expressing murine apoE. Error bars represent SEM.