. 2005 Apr 6;25(14):3560–3570. doi: 10.1523/JNEUROSCI.4354-04.2005

Table 1.

Quantification of wild-type Shank3 and Shank3 mutant-induced filopodia and spines and modulatory effects of glutamate receptor antagonists

Shank	Number of spines per 100 μm	(Spines/filopodia) × 100
Shank3	33.3 ± 1.5	75
ΔCort	16.9 ± 0.8^*	58^*
ΔAnk-SH3	25.9 ± 1.2^*	70
ΔNterm	8.1 ± 0.4^**	25^**
Homer region	0^**	0^**
Cterm	0^**	0^**
DNQX	6.1 ± 0.3^**	35^**
MK801	3.9 ± 0.2^**	30^**
CPCCOEt	6.6 ± 0.3^**	53^*

Values are means ± SEM obtained from 1300−10,500 protrusions (except the 0 values). Shank3, Wild-type Shank3; ΔCort, Shank3 mutant deleted of cortactin-binding site; ΔAnk-SH3, mutant deleted of the ankyrin plus SH3 domain; ΔNterm, Shank3 mutant deleted of the N terminus; Homer region, Homer-binding region of Shank3; Cterm, C-terminus of Shank3 containing the cortactin- and Abp1-binding sites plus SAM domain (detailed in Fig. 3A). DNQX, MK801, and CPCCOEt are antagonists of AMPA, NMDA, and mGluR1 receptors, respectively. ^*p≤0.05; ^**p≤0.01.