Table 1.
Biochemical analysis of PS1/APP and human AD brain tissue
|
|
Aβ1-40 (pmol/g wet weight) |
Aβ1-42 (pmol/g wet weight) |
Total Aβ (pmol/g wet weight) |
|---|---|---|---|
| Insoluble | |||
| PS1/APP (n = 4) | 35,002 ± 21,266 | 12,838 ± 8453 | 47,840 ± 05,288 |
| Human AD (n = 5) | 764 ± 455 | 1715 ± 565 | 2479 ± 904 |
| Soluble | |||
| PS1/APP (n = 4) | 1056 ± 602 | 573 ± 36 | 1629 ± 980 |
| Human AD (n = 5) | 5.4 ± 4.9 | 3.2 ± 2.73 | 8.6 ± 6.1 |
| % Soluble | |||
| PS1/APP (n = 4) | 3.9 ± 9.7% | 4.9 ± 9.5% | 4.2 ± 2.6% |
| Human AD (n = 5) |
0.73 ± 3.36% |
0.19 ± 9.06% |
0.36 ± 6.14% |