Figure 4.
Both IDE and p85 mRNA and protein levels were decreased in Tg2576 transgenic mice raised with safflower oil-based (Bad) diet compared with mice on standard diet, and the mRNA and protein levels of IDE and p85 were significantly correlated (A). In the Bad (B) diet-fed mice, the Aβ monomer levels were significantly increased compared with animals raised on standard (S) diet, and the levels of Aβ monomer and IDE were significantly inversely correlated, supporting the significance of IDE in Aβ degradation (B). *p ≤ 0.05 relative to standard.