Figure 7.
CF innervation of Purkinje cells in ORP150 genetically manipulated mice. A, Sample traces of CF-EPSCs recorded from ORP150+/-, ORP150+/+, and Tg ORP150 Purkinje cells. CFs were stimulated in the granular layer at 0.2 Hz, holding the potential at -20 mV. Two or three traces are superimposed at threshold stimulus intensity. B, Summary histograms showing the number of discrete steps of CF-EPSCs for ORP150+/- (open columns; n = 45), ORP150+/+ (shaded columns; n = 91), and Tg ORP150 (filled columns; n = 46) Purkinje cells. There was no significant difference in the distributions for the three types of Purkinje cells (p < 0.05, χ2 test for independent samples).