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. 2003 Nov 19;23(33):10568–10576. doi: 10.1523/JNEUROSCI.23-33-10568.2003

Figure 4.

Figure 4.

Altered molecular identity in the E14.5 Tlx, Gsh2, and Gsh2/Tlx mutant LGE. A, In the E14.5 wild-type telencephalon, Er81 is expressed in the dorsal LGE SVZ (arrows). In Tlx mutants (B), the Er81 expression domain is expanded both dorsally (Stenman et al., 2003b) and ventrally (arrows). Gsh2 mutants (C) and Gsh2/Tlx double mutants (D) lack SVZ expression of Er81 (C, D, asterisks). Note that Er81 expression in the Gsh2 mutants and Gsh2/Tlx double mutants is confined to the VZ. E, In the wild type, ISL1 expression is detected in the ventral LGE SVZ and in differentiating cells of the developing striatum (Stm). In Tlx mutants (F), the ISL1 expression is weaker and the expression domain is noticably reduced in size at this stage. G, Also, in Gsh2 mutants, fewer ISL1-positive cells are detected and even fewer in the Gsh2/Tlx double mutants (H). KO, Knock-out.