. 2003 Mar 15;23(6):2218–2227. doi: 10.1523/JNEUROSCI.23-06-02218.2003

Table 2.

ANOVA analysis of GO-annotated gene clusters

Gene group	Treatment	S-score (mean + SE)	Scheffe's post hoc
Calcium^2-159	Epil	−0.65 ± 0.12	p = 0.013 (vs Con)
(n = 62)	Dev	−1.07 ± 0.18	p< 0.0001 (vs Con)
	Con	−0.16 ± 0.09
Cell adhesion^2-214	Epil	0.07 ± 0.13	p = 0.005 (vs Dev)
(n = 29)	Dev	0.90 ± 0.29	p = 0.007 (vs Con)
	Con	0.10 ± 0.12
Channels^2-159	Epil	−0.05 ± 0.08	p = 0.0007 (vs Dev)
(n = 73)	Dev	−0.50 ± 0.09	p < 0.0001 (vs Con)
	Con	0.03 ± 0.07
Defense/stress^*	Epil	1.39 ± 0.41	p = 0.042 (vs Con)
(n = 20)	Dev	1.11 ± 0.36
	Con	0.30 ± 0.13
Neurotransmitter^2-159	Epil	−0.43 ± 0.10	p = 0.0029 (vs Con),
receptors	Dev	−1.14 ± 0.17	p = 0.0005 (vs Dev)
(n = 68)	Con	0.12 ± 0.11	p < 0.001 (vs Con)
Ribosomal^2-159	Epil	0.20 ± 0.09	p = 0.027 (vs Con),
(n = 112)	Dev	2.05 ± 0.10	p < 0.0001 (vs Dev)
	Con	−0.16 ± 0.11	p < 0.0001 (vs Con)
Synaptic/vesicle^2-214	Epil	0.31 ± 0.19	p = 0.0013 (vs Dev)
(n = 35)	Dev	−0.73 ± 0.26	p = 0.0128 (vs Con)
	Con	0.10 ± 0.14

Seven hundred twenty-two genes represented on the Affymetrix microarray, previously annotated by the Genome Organization (GO) and categorized into 15 different functional clusters, were analyzed by ANOVA. S-score values of repeated developmental (Dev), epileptogenic (Epil), or control (Con) comparisons were analyzed to identify clusters with significant differences among the three groups (p< 0.05) as shown above (n = number of genes in cluster). Scheffe's post hoc analysis indicates significant intragroup differences and respective p values. Other clusters analyzed that did not demonstrate significant differences were apoptosis (n = 25), cell cycle (n = 20), differentiation (n = 18), G-protein signaling (n = 15), metabolism (n = 72), neuropeptides (n = 10), signaling (n = 93), and transcription (n = 70).

ANOVA:

F2-159: p < 0.0005,

F2-214: p < 0.005,

p < 0.05.