Fig. 3.
Effects of ERC lesions on APP(+) dystrophic neurites. Sections through the dentate gyrus of sham (A,B) and lesioned (C, D) Tg mice contralateral and ipsilateral (B, D) to sham or ERC lesion were stained with APP695. APP(+) dystrophic neurites in plaques are significantly decreased on the side of ERC lesions, especially in the molecular layer of the dentate gyrus (D). E and F show that APP immunoreactivity (red) colocalizes with Aβ deposits (yellow) in slightly different compartments of amyloid plaques in double-labeled immunohistochemical preparations. MDG, Molecular layer of dentate gyrus;PoDG, polymorph layer of dentate gyrus. Scale bars:A–D, 100 μm; E, F, 50 μm.