Fig. 4.
Bar graphs representing Aβ (A,C) and APP(+) neurite (B,D) load in the dentate gyrus of intact, sham, and ERC-lesioned Tg mice. A and B represent values from total dentate, and C and Drepresent values from the polymorph and molecular layers separately in ERC-lesioned Tg mice. Proportional occupancy (burden) of dentate by Aβ- and APP-immunoreactive structures in plaques on the lesioned (sham, ERC lesions) or the right-sided dentate gyrus (intact) was expressed as a percentage of Aβ and APP burden on the contralateral side (the latter set as 100%). *p < 0.05; **p < 0.0001; by ANOVA. Significance is caused by a difference between sham and lesion or intact and lesion but not sham and intact.