Fig. 6.
APP and Aβ protein levels in dentate gyrus after ERC lesions. A, B, Western blots showing APP (top) and Aβ (middle) levels in homogenates of dentate gyrus ipsilateral (left lanes) and contralateral (right lanes) to ERC lesions. α-Tubulin (bottom) was run as loading control.B, Bar graphs of APP and total Aβ protein levels in ipsilateral and contralateral to ERC lesion by Western blot analysis. *p < 0.05; **p < 0.005 (comparison between lesion and contralateral side). C, Measurements of normal synapse density in the molecular and polymorph layers of the dentate gyrus 1 month after ERC lesions show no difference between lesioned and contralateral side. This is evidence that APP and Aβ proteins studied in A andB originated approximately in the same number of synapses in the two sides.