Fig. 3.
Normal performance of the α5 −/− mice in the elevated plus maze. a, Data shown are mean (±SEM) values for percentage time spent in (left panel) and number of entries made to (right panel) different areas of the elevated plus-maze by WT and α5 −/− mice (n = 20–23). There were no significant differences between WT and α5 −/− mice on any of the measures. b, Data shown are mean (± SEM) values for percentage time spent in (left panel) and number of entries made to (right panel) different areas of the elevated plus-maze by 10.0 mg/kg CDP or vehicle-treated WT and α5 −/− mice (n = 13–20). CDP had a significant anxiolytic-like effect of the same magnitude in both WT and α5 −/− mice (*). This is indicated by the increase in the percentage of time spent in (p < 0.01) and percentage of entries made to (p < 0.01) the open arms of the plus-maze in comparison with vehicle-treated WT and α5 −/− mice.