Table 1.
Effect of intra-accumbal microinjection of the AMPA antagonist CNQX, the NMDA antagonist AP-5, or their vehicles (1% DMSO or 0.9% saline, respectively) as well as intra-mPFC flupenthixol or saline on food-reinforced operant responding in the rat
| Drug or vehicle | n | Lever presses per minute |
|---|---|---|
| Nucleus accumbens | ||
| Saline | 10 | 23.5 (2.5) |
| 1% DMSO | 6 | 22.7 (3.5) |
| 0.3 μg CNQX | 6 | 43.5 (2.1)* |
| 3 μg AP-5 | 6 | 22.1 (1.8) |
| 30 μg AP-5 | 4 | 13.4 (1.4) |
| mPFC | ||
| Saline | 5 | 21.0 (4.1) |
| 30 μg Flupenthixol | 5 | 15.1 (2.5) |
The data are represented as the average number of food pellets dispensed per minute (±SEM) for 1 hr after the intra-accumbal microinjection. Note that intra-accumbal CNQX produced a significant increase in lever pressing maintained by food. *Significant difference from the 1% DMSO treatment (p < 0.05; Tukey's HSD).