Fig. 7.
A, Total number of neurons in area 38 (gray matter) of control (CON) and TLE specimens.B, Density of neurons in area 38 (gray matter) expressed per cubic millimeter. Density is significantly increased in TLE neocortex as compared with controls (*p = 0.023;t test, F(−2.563,14) = 0.147). C, Mean somal volume (expressed as cubic micrometers) of neurons as estimated with the nucleator. Neurons in TLE cortex are significantly larger than those in control material (***p < 0.0001, Mann–Whitney Utest). D, Proportion of small (diameter, <10 μm), medium (diameter, 10–15 μm), and large (diameter, >15 μm) neurons in the gray matter of area 38 in control (CON) and TLE neocortex. The proportion that are medium-sized is significantly decreased (*p = 0.03;t test; F(−2.41,14) = 0.734), whereas that of large neurons is significantly increased (*p = 0.001, t test;F(−6.347,14) = 1.847) in TLE cortex when compared with controls.