Table 3.
Summary of auditory system phenotypes in mice lacking TRα1 (Thratm1/tm1), TRβ (Thrbtm1/tm1), or both TRα1 and TRβ (Thratm1/tm1Thrbtm1/tm1)
| Phenotype | Severity in TR-deficient mouse strains | ||
|---|---|---|---|
| Thratm1/tm1 | Thrbtm1/tm1 | Thratm1/tm1Thrbtm1/tm1 | |
| ABR impaired | − | ++ | +++ |
| Tectorial membrane deformed | ND | + | +++ |
| Inner sulcus, delayed differentiation | ND | + | ++ |
| IHC,IK,f expression retarded | − | ++ | ++ |
| OHC, nonlinear capacitance impaired | − | + | ++ |
| Endocochlear potential reduced | − | − | + |
(−), No phenotype detected; (+), (++), or (+++) indicate presence of phenotype and approximate severity (+++, most severe); ND, not determined; IHC, inner hair cell; OHC, outer hair cell.