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Hippocampal plaque formation in different lines of FAD-mutant hAPP mice. Aβ deposits were detected by immunostaining of brain sections (n = 3 per mouse) with the 3D6 antibody as described in Materials and Methods. Six to 18 mice per line were analyzed at 2–4, 8–10, and 21–25 months of age, and 1–6 (mean = 4.3) mice per line were analyzed at 5–7 and 11–16 months of age.
