Fig. 4.
Pharmacology of agonist-induced [Ca2+]i increases. A, Bath-applied (20 sec) muscimol (10 μm) mimics the response to GABA (200 μm). B, Bicuculline (100 μm) reversibly abolishes the GABA-evoked [Ca2+]i rise. C, The response to glycine (1 mm) is suppressed by strychnine (10 μm). D, Bicuculline does not evoke a major suppression of the [Ca2+]i increase caused by glycine, whereas strychnine does not influence the response to GABA. E, Statistical analysis of the percentage antagonist-induced reduction of the GABA and glycine responses.F, Statistical analysis of the response to baclofen and muscimol, represented as the percentage of the peak [Ca2+]i rise elicited by GABA.