Table 1.
Dopaminergic components in RIIβ knock-out striatum
| Component | Wild-type | RIIβ mutant | Units |
|---|---|---|---|
| Dopamine | 41.9 ± 5.6 | 38.5 ± 3.4 | ng/mg protein |
| D1 receptor (Bmax): | |||
| DL | 50.4 ± 7.6 | 35.7 ± 2.1 | fmol/mg tissue |
| DM | 47.1 ± 7.2 | 39.9 ± 3.4 | fmol/mg tissue |
| VL | 45.0 ± 6.7 | 38.0 ± 5.5 | fmol/mg tissue |
| VM | 42.2 ± 6.5 | 38.4 ± 3.9 | fmol/mg tissue |
| D2 receptor (Bmax): | |||
| DL | 41.8 ± 2.7 | 36.5 ± 3.2 | fmol/mg tissue |
| DM | 32.9 ± 1.8 | 28.2 ± 2.6 | fmol/mg tissue |
| VL | 33.4 ± 1.1 | 32.9 ± 2.3 | fmol/mg tissue |
| VM | 27.8 ± 1.1 | 26.4 ± 1.3 | fmol/mg tissue |
| Dopamine transporter: | |||
| DA uptake | 0.81 ± 0.19 | 0.93 ± .34 | pmol/min per mg of protein |
| Amphetamine inhibition (IC50) | 0.16 ± .07 | 0.19 ± .11 | μm amphetamine |