. 1998 Sep 15;18(18):7099–7110. doi: 10.1523/JNEUROSCI.18-18-07099.1998

Table 3.

Results from dose–response simulations

Conditions	Dose vs P_o	Dose vs flux
(1) vary [Glu_out]
	K = 3 μm	K = 3.1 μm
[Na⁺_out] = 146 mm
[K⁺_in] = 140 mm	n = 1	n = 1
[Na · Glu_in] = 10 mm

(2) vary [Na⁺_out]
	K = 14 mm	K = 22 mm
[Glu_out] = 30 μm
[K⁺_in] = 140 mm	n = 2.6	n = 1.8
[Na · Glu_in] = 0 mm

(3) vary [H⁺_out]
	K = 4.1 nm	K = 2.4 nm
[Glu_out] = 100 μm
[Na⁺_out] = 146 mm	n = 1.3	n = 1
[K⁺_in] = 140 mm
[Na · Glu_in] = 10 mm

(4) vary [K⁺_out]
	K = 27 mm	K = 25 mm
[Glu_out] = 0 μm
[Na⁺_out] = 80 mm	n = 1.1	n = 1
[K⁺_in] = 0 mm
[Na · Glu_in] = 10 mm

Dose dependencies for glutamate, Na⁺, H⁺, or K⁺ ions were simulated for steady-state P_o or steady-state flux under the indicated conditions. An equation of the form:

R = R_{max} \cdot [ion]^{n} / ([ion]^{n} + K^{n}),

was fit to simulated [ion] versus response relationships where K and n were allowed to vary, and R_max was fixed at the maximal response value. In all conditions pH_in was set at 7.3; in all conditions except (3), pH_out was 7.4; and in all except (4), [K⁺_out] was set at 2.5 mm.