Table 2.
Comparison of decidual leukocyte populations between decidua in the first, second, and third trimesters of pregnancy.
| Cell type | Marker | Stage of pregnancy | Biopsy | Method | References | ||
|---|---|---|---|---|---|---|---|
| First trimester (%) | Second trimester (%) | Third trimester (%) | |||||
| NK | CD56 | 84.5 (77.8–88.5) | 50.4 (37.9–58.1) | Remain stable | Decidua | FACS | Bartmann et al. (53) |
| CD56 | 45.2 ± 2.8 | 48.7 ± 4.0 | 29.0 ± 3.3 | Decidua basalis | Immunohistochemical | Williams et al. (120) | |
| Macrophage | CD14s | 34.4 ± 2.8 | 33.3 ± 1.9 | 17.3 ± 1.2 | Decidua Basalis | Immunohistochemical | Williams et al. (120) |
| CD14 | 9.1 (5.0–14.0) | 18.2 (12.9–24.2) | Remain stable | Decidua | FACS | Bartmann et al. (53) | |
| Th17 CD4+ T cell | IL-17 | 0.31 ± 0.06 | Periphery Blood | Flow cytometry | Santner-Nanan et al. (151) | ||
| Treg | CD4+CD25high | 3.12 ± 0.26 | Peripheral blood | Flow cytometry | Santner-Nanan et al. (151) | ||
| CD4+CD127lowCD25+ | 6.98 ± 0.42 | Peripheral blood | Flow cytometry | Santner-Nanan et al. (151) | |||
| CD4+Foxp3+ | 6.26 ± 0.32 | Peripheral blood | Flow cytometry | Santner-Nanan et al. (151) | |||
| αβ T cells | 8.2 (5.4–11.0) | / | 26.7 (20.7–39.7) | Decidua | FACS | Bartmann et al. (53) | |
| CD8+T cells | 17.3 (12.4–23.9) | 17.3 (12.4–23.9) | 24.6 (20.5–32.6) | Decidua | FACS | Bartmann et al. (53) | |
| CD8+T cells | 31.7 ± 3.1 | 27.0 ± 4.6 | 34.8 ± 5.5 | Decidua basalis | Immunohistochemical | Williams et al. (120) | |
| CD3+T cells | 34.9 ± 3.7 | 34.6 ± 4.9 | 40.3 ± 6.8 | Decidua basalis | Immunohistochemical | Williams et al. (120) | |
This table describes the proportions of major leukocytes in the decidua during different stages of pregnancy. NK cells are the most abundant in the first and second trimester, where they participate in trophoblast invasion and spiral arterial remodeling, and they decrease as pregnancy progresses. Macrophages are the second major cells in the maternal-fetus interface in the first trimester, and they are stable throughout gestation. T cells have different subtypes that can play totally different functions in a successful pregnancy. The table describes the subsets of T cells and the dynamic changes in their proportions during pregnancy. Studies on the dynamic changes of DC are rare, and we do not provide information on the dynamic changes of DC.