Table 2.
Inter-reader precision and U-net segmentation accuracy shown as mean DSC obtained for the SNpc and midbrain in healthy controls and PD patients of both datasets
| Dataset | Structure | Mean DSC Reader 1 versus reader 2 |
Mean DSC U-net versus reader 1 |
||||||
|---|---|---|---|---|---|---|---|---|---|
| All | HC | PD | p value* | All | HC | PD | p value* | ||
| Principal |
MB SNpc |
0.97 ± 0.01 0.83 ± 0.04 |
0.97 ± 0.01 0.85 ± 0.04 |
0.97 ± 0.01 0.81 ± 0.04 |
0.974 < 0.001 |
0.97 ± 0.01 0.83 ± 0.04 |
0.97 ± 0.01 0.84 ± 0.03 |
0.97 ± 0.02 0.82 ± 0.04 |
0.868 0.001 |
| External validation |
MB SNpc |
0.96 ± 0.02 0.85 ± 0.03 |
0.95 ± 0.02 0.86 ± 0.02 |
0.96 ± 0.02 0.83 ± 0.03 |
0.563 0.036 |
0.95 ± 0.01 0.79 ± 0.04 |
0.96 ± 0.01 0.80 ± 0.05 |
0.95 ± 0.02 0.77 ± 0.03 |
0.532 0.101 |
Data are presented as mean ± standard deviation unless otherwise noted
DSC, Dice similarity coefficient; HC, healthy controls; MB, midbrain; PD, Parkinson’s disease; SNpc, substantia nigra pars compacta
*Between HC and PD patients