Table 5.
Statistics for pS-α-syn-RBC in diagnosis and subtyping analyzing of MSA.
| Comparison | pS-α-syn-RBC (ng/mg, Mean ± S.D) | AUC (95% CI) | p-value | Cut-off∗ (ng/mg) | Sensitivity (%, 95% CI) | Specificity (%, 95% CI) | PPV (%, 95%CI) | NPV (%, 95% CI) | LR (+)† | LR (−)‡ |
|---|---|---|---|---|---|---|---|---|---|---|
| MSA/Control | 14.02 ± 4.02/11.89 ± 3.57 | 0.91 (0.87–0.94) | <0.001 | 10.90 | 80.37 (71.58–87.42) | 88.64 (83.68–92.51) | 81.87 (74.65–87.99) | 87.62 (81.43–92.10) | 7.07 | 0.22 |
| MSA-P/MSA-C | 13.27 ± 1.91/12.19 ± 3.04 | 0.65 (0.53–0.78) | =0.025 | 12.08 | 57.14 (40.96–72.28) | 75.76 (57.74–88.91) | 63.87 (49.44–76.23) | 70.21 (49.22–86.70) | 2.36 | 0.57 |
∗The cur-off values were determined by Youden's suggested index. †LR (+) = sensitivity/1-specificity. ‡NPV = LR (−) = 1-sensitivity/specificity. Bold: p < 0.05. pS-α-syn-RBC, phosphorylated α-syn in RBC; AUC, area under curve; PPV, positive predictive value; NPV, negative predictive value; LR (+), positive likelihood ratio; LR (−), negative likelihood ratio.