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. 1992 Jun;14(6):1240–1250. doi: 10.1093/clinids/14.6.1240

Infection with Borna Disease Virus: Molecular and Immunobiological Characterization of the Agent

J A Richt 1, S VandeWoude 1, M C Zink 1, J E Clements 1, S Herzog 1, L Stitz 1, R Rott 1, O Narayan 1,
PMCID: PMC7109702  PMID: 1623080

Abstract

Borna disease virus (BDV), which seems to be distinct from all other known viruses, exhibits a unique mechanism of pathogenesis. This review highlights several aspects of the biology of infection with this virus and summarizes the preliminary characterization of the agent. Studies on BDV may help to illuminate several important areas of neurobiology, including the mechanisms regulating the replication of a new type of RNA virus in the nuclei of neural cells, the neuroinvasiveness and neurotropism of such viruses, their T cell-mediated immunopathology, tolerance in newborn animals to persistent viral infection of the central nervous system, and behavioral diseases and eating disorders induced by such agents.


Articles from Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America are provided here courtesy of Oxford University Press

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