Table 1.
Viral titers within brains of MHV-infected mice
| Mouse | Days postinfection | Viral titer log10 (PFU/g)a | n |
|---|---|---|---|
| Wild type infected | 5 | 5.7 ± 0.09 | 8 |
| 7 | 5.5 ± 0.08 | 22 | |
| 10–12 | 3.0 ± 0.52 | 10 | |
| CCL2−/− infected | 5 | 5.9 ± 0.09 | 7 |
| 7 | 5.7 ± 0.11 | 9 | |
| 10–12 | 3.1 ± 0.33 | 7 | |
| CCR2−/− infected |
5 | 6.0 ± 0.03b | 9 |
| 7 | 6.0 ± 0.16c | 9 | |
| 10–12 | 4.5 ± 0.18d | 4 |
a
All titer data are presented as mean ± SEM. No virus was detected from sham mice of all groups.
b
P ≤ 0.002 as compared to wild type at day 5 pi; not significant compared to CCL2−/− mice.
c
P ≤ 0.003 as compared to wild type at day 7 pi; not significant compared to CCL2−/− mice.
d
P ≤ 0.01 as compared to wild type at days 10–12 pi; P ≤ 0.02 as compared to CCL2−/− at days 10–12 pi.