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Co-crystals of Nsp15 K289A mutant protein without (A) and with RNAs (B, C). SLT is an tightly folded RNA of 35-nt (Kim et al., 2001) while poly(I:C) is a chemically synthesized RNA of 40 bps. The boxes in each panel define a unit cell. Note that the structures of each of the protein differed with the RNA bound, suggesting that Nsp15 could adjust its conformation in response to the RNA.
